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PeliMers, MHC多聚体
Sanquin是世界上MHC四聚体的主要供应商。除提供重组MHC外，Sanquin还为客户定制 MHC-Peptide化合物，它能根据客户所提供的肽序列，合成特殊的MHC-Peptide化合物。
MHC四聚体是第一种可在流式中鉴别抗原特异性T细胞的试剂，其革命性改进了免疫学研究。该技术逐渐被认为是定量T细胞免疫反应的金标准。其最初的文献（Phenotypic Analysis of Antigen-Specific T Lymphocytes; Altman, John et. al. Science 1996 274: 94-96.）已被引用超过500次。用MHC-肽四聚体可在流式细胞仪上从大量细胞中检测和分离抗原特异性T细胞。可用于分析新鲜或冰冻细胞。不仅节约时间，而且更精确。细胞表型分析可以与细胞内细胞因子检测同时分析，使您在一次分析中了解细胞的特性和激活状态。
1999年, Sanquin与荷兰肿瘤研究所 (NKI)合作开发了该系列产品。并提供各种包装Pelimers MHC四聚体（10 Test、50 Test、250 Test）。
Sanquin提供各种包装Pelimers MHC四聚体（10 Test, 50 Test, 250 Test）。
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Human |
Epitope |
Allele |
Description |
Order code |
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Virus antigens |
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FLU |
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CTELKLSDY |
A*0101 |
PeliMer A1/FLU PE |
M2425CTELK |
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VSDGGPNLY |
A*0101 |
PeliMer A1/FLU PE |
M2425VSDGG |
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HIV |
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SLYNTVATL |
A*0201 |
PeliMer A2/HIV-gag PE |
M2427SLYNT |
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SLYNTVATL |
A*0201 |
PeliMer A2/HIV-gag APC |
M2428SLYNT |
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RLRPGGKKK |
A*0301 |
PeliMer A3/HIV-gag PE |
M2429RLRPG |
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RLRPGGKKK |
A*0301 |
PeliMer A3/HIV-gag APC |
M2430RLRPG |
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IVLPEKDSW |
B*5701 |
PeliMer B57/HIV-pol PE |
M2439IVLPE |
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KAFSPEVIPMF |
B*5701 |
PeliMer B57/HIV-gag PE |
M2439KAFSP |
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CMV |
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NLVPMVATV |
A*0201 |
PeliMer A2/CMV (pp65) |
M2427NLVPM |
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EBV |
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RLRAEAQVK |
A*0301 |
PeliMer A3/EBV PE |
M2429RLRAE |
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KIRLRPGGK |
A*0301 |
PeliMer A3/EBV APC |
M2430KIRLR |
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IVTDFSVIK |
A*1101 |
PeliMer A11/EBV PE |
M2431IVTDF |
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AVFDRKSDAK |
A*1101 |
PeliMer A11/EBV PE |
M2431AVFDR |
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AVFDRKSDAK |
A*1101 |
PeliMer A11/EBVAPC |
M2432AVFDR |
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RPPIFIRRL |
B*0702 |
PeliMer B7/EBV PE |
M2433RPPIF |
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RPPIFIRRL |
B*0702 |
PeliMer B7/EBV APC |
M2434RPPIF |
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RAKFKQLL |
B*0801 |
PeliMer B8/EBV PE |
M2435RAKFK |
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EPLPQGQLTAY |
B*3501 |
PeliMer B35/BZLF1 PE |
M2437EPLPQ |
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HPVGEADYFEY |
B*3501 |
PeliMer B35/EBNA1 PE |
M2437HPVGE |
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RSV |
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* |
A*0201 |
PeliMer A2/RSV APC |
M2428O2927 |
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* |
B*0702 |
PeliMer B7/RSV APC |
M2434O2936 |
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TPKGPSLRV |
B*0702 |
PeliMer B7/RSV APC |
M2434TPKGP |
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HBV |
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FLLSLGIHL |
A*0201 |
PeliMer A2/HBV-pol PE |
M2427FLLSL |
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FLPSDFFPSV |
A*0201 |
PeliMer A2/ HBV-core PE |
M2427FLPSD |
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WLSLLWPFV |
A*0201 |
PeliMer A2/ HBV-env PE |
M2427WLSLL |
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HPV |
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KLPQLCTEL |
A*0201 |
PeliMer A2/HPV PE |
M2427KLPQL |
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Tumour antigens |
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TUMOUR |
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YMDGTMSQV |
A*0201 |
PeliMer A2/ Tyrosinase PE |
M2427YMDGT |
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RMFPNAPYL |
A*0201 |
PeliMer A2/ WT-1 PE |
M2427RMFPN |
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Murine |
Epitope |
Allele |
Description |
Order code |
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SIINFEKL |
H2-Kb |
PeliMer H2-Kb / OVA APC |
M2711SIINF |
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SVYDFFVWL |
H2-Kb |
PeliMer H2-Kb /TRP-2 APC |
M2711SVYDF |
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ASNENMDAM |
H2-Db |
PeliMer H2-Db /F5 PE |
M2712ASNEN |
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KCSRNRQYL |
H2-Db |
PeliMer H2-Db / HY PE |
M2712KCSRN |
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RAHYNIVTF |
H2-Db |
PeliMer H2-Db / PE |
M2712RAHYN |
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ASNENMDAM |
H2-Db |
PeliMer H2-Db / F5 APC |
M2713ASNEN |
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KCSRNRQYL |
H2-Db |
PeliMer H2-Db / HY APC |
M2713KCSRN |
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